中国·威尼斯(37000cm-VIP认证)网站-Made in China

高明-博士研究生导师









高明

 

职称:主任医师、教授、博士生导师

 

 

教育经历

 

1.19859月—19907,天津37000cm威尼斯临床37000cm威尼斯,临床医学,本科

 

2.19929月—19957月,天津医科大学研究生院,肿瘤学,研究生

 

3.19966月—199610月,香港大学QueenMary Hospital,头颈外科,访问学者

 

4.20019月—20047月,天津医科大学研究生院,肿瘤学,博士研究生

 

5.200910月—20105月,美国麻省FitchburgState College,肿瘤学,访问学者

 

工作经历

 

1. 19907月—199610月,天津医科大学肿瘤医院,头颈肿瘤外科,医师

 

2. 199611月—200010月,天津医科大学肿瘤医院,头颈肿瘤外科,主治医师

 

3. 200011月—20054月,天津医科大学肿瘤医院,头颈肿瘤外科,科主任助理,副主任医师

 

4. 20055月—200711月,天津医科大学肿瘤医院,甲状腺外科,科主任

 

5. 200712月—20209月,天津医科大学肿瘤医院,副院长

 

6. 202010月—20238月,天津市人民医院(南开大学人民医院),党委副书记、院长

 

7. 20238月—至今,天津市人民医院(南开大学人民医院),党委书记、院长

 

 

研究方向(包括承担课题项目)

 

研究方向:

 

甲状腺癌生物学机制及转化研究:主要包括:1.基因组学介导的甲状腺癌分子分型;2.甲状腺癌分化演进的分子机制研究;3.晚期甲状腺癌靶向药物的药代动力学及耐药机制的研究;4.甲状腺癌易感基因的筛查及大数据体系的建立四个方向,对甲状腺癌的生物学行为机制进行深入研究,寻找分化演进在甲状腺癌发生发展中的关键节点,并寻找难治性甲状腺癌治疗的可能的新靶点。

 

甲状腺癌多元化精准诊断策略研究:主要包括:1.甲状腺癌超声影像精准诊断策略研究;2.高危甲状腺微小癌病理学精准筛查策略;3.基于分子分型的甲状腺癌危险度分层的精准评估三个方面对甲状腺癌的术前超声诊断、术后病理细化分型以及甲状腺癌分子分型做出研究。

 

甲状腺癌精准治疗体系的完善:主要包括:1.完善分化型甲状腺癌精准治疗体系;2.甲状腺癌临床治疗难点的研究,进一步将甲状腺癌的分子分型及评估体系应用于临床,最终实现个体化的诊疗选择,形成同诊断、治疗、术后随访的精准诊疗策略。

 

 

承担课题:

 

1. SETMAR通过组蛋白甲基化调控SMARCA2诱导甲状腺未分化癌分化改善放射性碘治疗抵抗的相关机制研究(国家自然科学基金面上项目,项目负责人,2024.01-2027.12 项目编号 82372753 项目经费49万元)

 

2. 甲状腺癌免疫特征的危险分层及联合免疫治疗的新策略

天津市卫健委重点学科专项,项目负责人,2022.7-2025.6,项目编号 TJWJ2022XK024项目经费50万元)

 

3. 甲状腺癌分化演进的分子机制及治疗策略;

(天津市科委重点项目,项目负责人,2022.1-2025.12,项目编号 21JCZDJC00360,项目经费40万)

 

4. C14X基因在甲状腺发育和肿瘤发生中的功能研究;

(国家自然科学基金资助项目,项目负责人,2015.01-2018.12 项目编号 81472580 项目经费70万元)

 

5. 家族性非髓样甲状腺癌候选致病基因的验证与功能研究;

(国家自然科学基金资助项目,项目负责人,2013.01-2016.12 项目编号 81272282 项目经费77万元)

 

6. 甲状腺癌多学科精准诊疗体系的建立

2017年“十三五”综投项目,项目负责人,2017.11-2021.12,项目经费250万元)

 

7. 高侵袭性甲状腺癌的分子鉴别及精准诊疗策略制定

2017年天津市重点研发计划科技支撑重点项目,项目负责人,2017.04-2020.03合同编号17YFZCSY00690项目经费100万元,医院配比50万元)

 

8. 高侵袭性分化型甲状腺癌的分子识别及候选基因全外显子测定;

2014年国家肿瘤临床医学研究中心培育项目,第一负责人,2014.04-2017.03,项目经费10万元)

 

9. SDHBSDHCSDHD基因与国人副神经节瘤相关性研究;

(天津市科技计划项目,编号09JCYBJC10300,项目负责人,2009.01-2012.01项目经费10万元)

 

10. 阿帕替尼联合维莫非尼治疗BRAF突变的晚期分化型甲状腺癌的多中心前瞻性临床研究

2017天津医科大学肿瘤医院医院临床试验基金重点项目,项目负责人,2017.06-2020.03,项目经费167万元)

 

11. 甲硫酸阿帕替尼片治疗局部进展/转移性分化型甲状腺癌患者有效性和安全性临床研究

(与中国抗癌会横向合作,2017.022019.01,项目负责人,项目经费20万元)

 

12. 肿瘤细胞MDMX异常调控的分子生物学机制

2012年天津市应用基础与前沿技术研究计划青年基金项目第五负责人)

 

13. 家族性非髓样甲状腺癌致病候选基因的筛选验证

(天津市高等学校科技发展基金计划项目第二负责人项目编号:20110127

 

14. 甲状腺髓样癌高发家系的分子遗传学研究

2008年天津医科大学校级课题;第一负责人)

 

 

学术兼职

 

1. 中华医学会肿瘤学分会,副主任委员

2. 中华医学会肿瘤学分会甲状腺肿瘤专业委员会,主任委员

3. 中国抗癌协会甲状腺癌专业委员会,第一届主任委员,第三届候任主委

4. 中国抗癌协会头颈肿瘤专业委员会,第八届前任主委

5. 中国抗癌协会理事会,常务理事

6. 天津市抗癌协会甲状腺癌专业委员会,主任委员

 

 

近五年发表的学术论文

 

2023

 

Li L, Wu N, Zhuang G, Geng L, Zeng Y, Wang X, Wang S, Ruan X, Zheng X, Liu J, Gao M. Heterogeneity and potential therapeutic insights for triple-negative breast cancer based on metabolic-associated molecular subtypes and genomic mutations. Front Pharmacol. 2023 Sep 1;14:1224828. doi: 10.3389/fphar.2023.1224828IF: 5.6 Q1 . PMID: 37719859; PMCID: PMC10502304.

 

Ning J, Hou X, Hao J, Zhang W, Shi Y, Huang Y, Ruan X, Zheng X, Gao M. METTL3 inhibition induced by M2 macrophage-derived extracellular vesicles drives anti-PD-1 therapy resistance via M6A-CD70-mediated immune suppression in thyroid cancer. Cell Death Differ. 2023 Aug 30. doi: 10.1038/s41418-023-01217-xIF: 12.4 Q1 . Epub ahead of print. PMID: 37648786.

 

Lu S, Zheng X, Sun Y, Huang D, Wu L, Ji Q, Zhou C, Zhou J, Guo Y, Ge M, Ding D, Shao J, Zhang W, Gao M, Cheng Y. Patient-reported outcomes following selpercatinib treatment in Chinese patients with advanced RET fusion-positive non-small-cell lung cancer and thyroid cancer, and RET-mutant medullary thyroid cancer in the phase II LIBRETTO-321 trial. Ther Adv Med Oncol. 2023 Aug 25;15:17588359231189429. doi: 10.1177/17588359231189429IF: 4.9 Q2 . PMID: 37655205; PMCID: PMC10467255.

 

Chi Y, Zheng X, Zhang Y, Shi F, Cheng Y, Guo Z, Ge M, Qin J, Zhang J, Li Z, Zhou X, Huang R, Chen X, Liu H, Cheng R, Xu Z, Li D, Tang P, Gao M. Anlotinib in Locally Advanced or Metastatic Radioiodine-Refractory Differentiated Thyroid Carcinoma: A Randomized, Double-Blind, Multicenter Phase II Trial. Clin Cancer Res. 2023 Oct 13;29(20):4047-4056. doi: 10.1158/1078-0432.CCR-22-3406IF: 11.5 Q1 . PMID: 37594724; PMCID: PMC10570678 .

 

Hou X, Tian M, Ning J, Wang Z, Guo F, Zhang W, Hu L, Wei S, Hu C, Yun X, Zhao J, Dong Q, Ruan X, Li D, Gao M, Zheng X. PARP inhibitor shuts down the global translation of thyroid cancer through promoting Pol II binding to DIMT1 pause. Int J Biol Sci. 2023 Jul 31;19(12):3970-3986. doi: 10.7150/ijbs.81895IF: 9.2 Q1 . PMID: 37564214; PMCID: PMC10411462.

 

Fu G, Li X, Guo F, Ruan X, Zhang W, Zhang W, Zhang Y, Chen Y, Li C, Chen J, Zheng X, Wang Z, Gao M. Partial preservation of the normal thyroid gland based on tumor diameter may be possible in small medullary thyroid carcinoma: a two-center 15-year retrospective study. Front Oncol. 2023 Jul 13;13:1216394. doi: 10.3389/fonc.2023.1216394IF: 4.7 Q2 . PMID: 37519823; PMCID: PMC10374252.

 

Ning J, Hao J, Guo F, Hou X, Li L, Wang J, Wang S, Gao Y, Zheng X, Gao M. ABCB11 accumulated in immature tertiary lymphoid structures participates in xenobiotic metabolic process and predicts resistance to PD-1/PD-L1 inhibitors in head and neck squamous cell carcinoma. Transl Oncol. 2023 Oct;36:101747. doi: 10.1016/j.tranon.2023.101747IF: 5.0 Q2 . Epub 2023 Jul 28. PMID: 37517143; PMCID: PMC10407442.

 

Hao W, Zhao J, Guo F, Zhang J, Gu P, Ruan X, Zhang W, Zheng X, Gao M. The survival outcomes of prophylactic lateral neck dissection for medullary thyroid carcinoma, a retrospective cohort study. Clin Otolaryngol. 2023 Sep;48(5):734-739. doi: 10.1111/coa.14053IF: 2.1 Q3 . Epub 2023 Jun 27. PMID: 37366234.

 

Ma W, Tian M, Hu L, Ruan X, Zhang W, Zheng X, Gao M. Early Combined SHP2 Targeting Reverses the Therapeutic Resistance of Vemurafenib in Thyroid Cancer. J Cancer. 2023 May 29;14(9):1592-1604. doi: 10.7150/jca.83853IF: 3.9 Q2 . PMID: 37325052; PMCID: PMC10266257.

 

Yang Z, Liu R, Qiu M, Mei H, Hao J, Song T, Zhao K, Zou D, Wang H, Gao M. The roles of ERIANIN in tumor and innate immunity and its' perspectives in immunotherapy. Front Immunol. 2023 Apr 28;14:1170754. doi: 10.3389/fimmu.2023.1170754IF: 7.3 Q1 . PMID: 37187758; PMCID: PMC10175588.

 

Dong A, Gao M, Zheng X, Ruan X. Dysregulation of miR-551b-5p and SETD2 Predicts Poor Prognosis and Promotes Migration and Invasion of Thyroid Cancers. Endocr Metab Immune Disord Drug Targets. 2023;23(11):1400-1409. doi: 10.2174/1871530323666230417083509IF: 1.9 Q4 . PMID: 37073141.

 

Li Q, Feng T, Zhu T, Zhang W, Qian Y, Zhang H, Zheng X, Li D, Yun X, Zhao J, Li Y, Yu H, Gao M, Qian B. Multi-omics profiling of papillary thyroid microcarcinoma reveals different somatic mutations and a unique transcriptomic signature. J Transl Med. 2023 Mar 20;21(1):206. doi: 10.1186/s12967-023-04045-2IF: 7.4 Q1 . PMID: 36941725; PMCID: PMC10026500.

 

Hao W, Zhao J, Guo F, Gu P, Zhang J, Huang D, Ruan X, Zeng Y, Zheng X, Gao M. Value of lymph node ratio as a prognostic factor of recurrence in medullary thyroid cancer. PeerJ. 2023 Mar 13;11:e15025. doi: 10.7717/peerj.15025IF: 2.7 Q2 . PMID: 36935920; PMCID: PMC10019331.

 

Hao J, Wang S, Wang J, Zhang Z, Gao M, Wan Y. A novel autophagy-related long non-coding RNAs signature predicting progression-free interval and I-131 therapy benefits in papillary thyroid carcinoma. Open Med (Wars). 2023 Mar 3;18(1):20230660. doi: 10.1515/med-2023-0660IF: 2.1 Q3 . PMID: 36880066; PMCID: PMC9985460.

 

 

2022

 

Zhang W, Ruan X, Li Y, Zhi J, Hu L, Hou X, Shi X, Wang X, Wang J, Ma W, Gu P, Zheng X, Gao M. KDM1A promotes thyroid cancer progression and maintains stemness through the Wnt/β-catenin signaling pathway. Theranostics. 2022 Jan 3;12(4):1500-1517. doi: 10.7150/thno.66142. IF=11.600

 

Hu L, Zhang J, Tian M, Kang N, Xu G, Zhi J, Ruan X, Hou X, Zhang W, Yi J, Ma W, Chang L, Tang T, Zheng X, Wei X, Gao M. Pharmacological inhibition of Ref-1 enhances the therapeutic sensitivity of papillary thyroid carcinoma to vemurafenib. Cell Death Dis. 2022 Feb 8;13(2):124. IF=8.469

 

Xie W, Sun Y, Zeng Y, Hu L, Zhi J, Ling H, Zheng X, Ruan X, Gao M. Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer. Bioengineered. 2022 Jan;13(1):190-205. doi: 10.1080/21655979.2021.2012316. IF=6.832

 

Zhi J, Yi J, Hou X, Wang W, Yang W, Hu L, Huang J, Guo S, Ruan X, Gao M, Zheng X. Targeting SHP2 sensitizes differentiated thyroid carcinoma to the MEK inhibitor. Am J Cancer Res. 2022 Jan 15;12(1):247-264. IF=6.166

 

Huang D, Zhang J, Zheng X, Gao M. Efficacy and Safety of Lenvatinib in Anaplastic Thyroid Carcinoma: A Meta-Analysis. Front Endocrinol (Lausanne). 2022;13:920857. Published 2022 Jun 30. doi:10.3389/fendo.2022.920857.IF=6.055

 

Ruan X, Yi J, Hu L, Zhi J, Zeng Y, Hou X, Huang J, Gu P, Hao W, Gao M, Pan Y, Wei S, Zheng X. Reduced MHC class II expression in medullary thyroid cancer identifies patients with poor prognosis. EndocrRelat Cancer. 2022 Jan 20;29(2):87-98. IF=5.678

 

Xie W, Sun Y, Zeng Y, Hu L, Zhi J, Ling H, Zheng X, Ruan X, Gao M. Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer. Bioengineered. 2022 Jan;13(1):190-205. IF=3.269

 

2021

 

Dapeng Li; Yihebali Chi; Xiaohong Chen; Minghua Ge; Yuan Zhang;ZhumingGuo;Jun Wang; Jie Chen; Jiewu Zhang; Ying Cheng; Zhendong Li; Hui Liu;Jianwu Qin; Jingqiang Zhu; Ruochuan Cheng; Zhengang Xu; XiangqianZheng;Pingzhang Tang; Ming Gao;Anlotinib in Locally Advanced or Metastatic Medullary Thyroid Carcinoma: A Randomized, Double-Blind Phase IIB Trial, Clin Cancer Res.IF=12.533

 

Zheng X, Xu Z, Ji Q, Ge M, Shi F, Qin J, Wang F, Chen G, Zhang Y, Huang R, Tan J, Huang T, Li S, Lv Z, Lin Y, Guo Z, Kubota T, Suzuki T, Ikezawa H, Gao M. A Randomized, Phase III Study of Lenvatinib in Chinese Patients with Radioiodine-Refractory Differentiated Thyroid Cancer. Clin Cancer Res. 2021 Oct 15;27(20):5502-5509. doi: 10.1158/1078-0432.CCR-21-0761. IF=12.531

 

Xiukun Hou, Xianle Shi, Wei Zhang, Dapeng Li, Linfei Hu, Jihong Yang, Jingzhu Zhao, Songfeng Wei, Xi Wei, XianhuiRuan, Xiangqian Zheng, Ming Gao.LDHA induces EMT gene transcription and regulates autophagy to promote the metastasis and tumorigenesis of papillary thyroid carcinoma,Cell Death Dis. 2021 Apr 1;12(4):347.IF=8.461

 

Chi J, Zhao J, Wei S, Li Y, Zhi J, Wang H, Hou X, Hu L, Zheng X, Gao M. A CRISPR-Cas9-Based Near-Infrared Upconversion-Activated DNA Methylation Editing System. ACS Appl Mater Interfaces. 2021 Feb 10;13(5):6043-6052. doi: 10.1021/acsami.0c21223. Epub 2021 Feb 1. PMID: 33525876.IF=8.758

 

Ruan X, Tian M, Kang N, Ma W, Zeng Y, Zhuang G, Zhang W, Xu G, Hu L, Hou X, Xie W, Gao M, Piao Y, Guo S, Zheng X. Genome-wide identification of m6A-associated functional SNPs as potential functional variants for thyroid cancer. Am J Cancer Res. 2021 Nov 15;11(11):5402-5414. IF=6.166

 

Zhi J, Zhang P, Zhang W, Ruan X, Tian M, Guo S, Zhang W, Zheng X, Zhao L, Gao M. Inhibition of BRAF Sensitizes Thyroid Carcinoma to Immunotherapy by Enhancing tsMHCII-mediated Immune Recognition. J Clin Endocrinol Metab. 2021 Jan 1;106(1):91-107. doi: 10.1210/clinem/dgaa656. PMID: 32936899.IF=5.399

 

Zhang J, Sun B, Ruan X, Hou X, Zhi J, Meng X, Zheng X, Gao M. Oncoprotein HBXIP promotes tumorigenesis through MAPK/ERK pathway activation in non-small cell lung cancer. Cancer Biol Med. 2021 Feb 15;18(1):105-119.IF=4.240

 

Jiaoyu Yi, Mengran Tian, Linfei Hu, Ning Kang, Weike Ma, JingtaiZhi, Xiangqian Zheng, XianhuiRuan, Ming Gao.The mechanisms of celastrol in treating papillary thyroid carcinoma based on network pharmacology and experiment verification,Ann Transl Med. 2021 May;9(10):866. IF=3.932

 

Zhao J, Zheng X, Gao M, Zhang S, Yun X, Chi J, Xu G. Ultrasound features of medullary thyroid cancer as predictors of biological behavior. Cancer Imaging. 2021 Apr 9;21(1):33.IF=3.903

 

Zhu J, Zhang S, Yu R, Liu Z, Gao H, Yue B, Liu X, Zheng X, Gao M, Wei X. An efficient deep convolutional neural network model for visual localization and automatic diagnosis of thyroid nodules on ultrasound images. Quant Imaging Med Surg. 2021 Apr;11(4):1368-1380.IF=3.831

 

2020

 

Wang Y, Ma R, Liu B, Kong J, Lin H, Yu X, Wang R, Li L, Gao M, Zhou B, Mohan M, Yu H, Hou Z, Shen H, Qian B. SNP rs17079281 decreases lung cancer risk through creating an YY1-binding site to suppress DCBLD1 expression. Oncogene. 2020 May;39(20):4092-4102. doi: 10.1038/s41388-020-1278-4. Epub 2020 Mar 30. PMID: 32231272; PMCID: PMC7220863.IF=7.971

 

Zhang H, Zheng X, Liu J, Gao M, Qian B. Active surveillance as a management strategy for papillary thyroid microcarcinoma. Cancer Biol Med. 2020 Aug 15;17(3):543-554. doi: 10.20892/j.issn.2095-3941.2019.0470. PMID: 32944389; PMCID: PMC7476094.IF=5.432

 

Meng X, Wang H, Zhao J, Hu L, Zhi J, Wei S, Ruan X, Hou X, Li D, Zhang J, Yang W, Qian B, Wu Y, Zhang Y, Meng Z, Guan L, Zhang H, Zheng X, Gao M. Apatinib Inhibits Cell Proliferation and Induces Autophagy in Human Papillary Thyroid Carcinoma via the PI3K/Akt/mTOR Signaling Pathway. Front Oncol. 2020 Mar 11;10:217. doi: 10.3389/fonc.2020.00217. PMID: 32219060; PMCID: PMC7078169.IF=4.848

 

Zhi J, Yi J, Tian M, Wang H, Kang N, Zheng X, Gao M. Immune gene signature delineates a subclass of thyroid cancer with unfavorable clinical outcomes. Aging (Albany NY). 2020 Apr 2;12(7):5733-5750. doi: 10.18632/aging.102963. Epub 2020 Apr 2. PMID: 32240105; PMCID: PMC7185138.IF=4.831

 

Wu Y, Huang K, Zheng X, Gao M, Liu H. Tumor Biology is King: Secondary Tumors of the Thyroid From 2 Medical Centers in China. Cancer Control. 2020 Jul-Aug;27(3):1073274820945984. doi: 10.1177/1073274820945984. PMID: 32779493; PMCID: PMC7791472.IF=3.103

 

Zhi J, Wu Y, Hu L, Zhao J, Liu H, Ruan X, Hou X, Zhang J, Zheng X, Gao M. Assessment of the prognostic value and N1b changes of the eighth TNM/AJCC staging system for differentiated thyroid carcinoma. Int J Clin Oncol. 2020 Jan;25(1):59-66. doi: 10.1007/s10147-019-01522-x. Epub 2019 Aug 14. PMID: 31414270.IF=2.879

 

2019

 

Li X, Zhang S, Zhang Q, Wei X, Pan Y, Zhao J, Xin X, Qin C, Wang X, Li J, Yang F, Zhao Y, Yang M, Wang Q, Zheng Z, Zheng X, Yang X, Whitlow CT, Gurcan MN, Zhang L, Wang X, Pasche BC, Gao M, Zhang W, Chen K. Diagnosis of thyroid cancer using deep convolutional neural network models applied to sonographic images: a retrospective, multicohort, diagnostic study. Lancet Oncol. 2019 Feb;20(2):193-201. doi: 10.1016/S1470-2045(18)30762-9. Epub 2018 Dec 21. Erratum in: Lancet Oncol. 2020 Oct;21(10):e462. PMID: 30583848; PMCID: PMC7083202.IF=33.752

 

Zheng X*, Peng C, Gao M, Zhi J, Hou X, Zhao J, Wei X, Chi J, Li D, Qian B. Risk factors for cervical lymph node metastasis in papillary thyroid microcarcinoma: a study of 1,587 patients. Cancer Biol Med. 2019 Feb;16(1):121-130. doi: 10.20892/j.issn.2095-3941.2018.0125. PMID: 31119052; PMCID: PMC6528461. IF=5.432

 

Cao X, Dang L, Zheng X, Lu Y, Lu Y, Ji R, Zhang T, Ruan X, Zhi J, Hou X, Yi X, Li MJ, Gu T, Gao M, Zhang L*, Chen Y*. Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma. Thyroid. 2019 Jun;29(6):809-823. doi: 10.1089/thy.2018.0550. Epub 2019 May 3. PMID: 30924726.IF=5.227

 

Wei X, Cai S, Boohaker RJ, Fried J, Li Y, Hu L, Pan Y, Cheng R, Zhang S, Tian Y, Gao M, Xu B*. KAT5 promotes invasion and metastasis through C-MYC stabilization in ATC. EndocrRelat Cancer. 2019 Jan 1;26(1):141-151. doi: 10.1530/ERC-18-0193. PMID: 30400007.IF=4.8

 

Ruan X, Shi X, Dong Q, Yu Y, Hou X, Song X, Wei X, Chen L*, Gao M. Antitumor effects of anlotinib in thyroid cancer. EndocrRelat Cancer. 2019 Jan 1;26(1):153-164. doi: 10.1530/ERC-17-0558. PMID: 30139768; PMCID: PMC6215907. IF=4.8

 

Zhao J, Yun X, Ruan X, Chi J, Yu Y, Li Y, Zheng X, Gao M. High expression of NUCB2 promotes papillary thyroid cancer cells proliferation and invasion. Onco Targets Ther. 2019 Feb 18;12:1309-1318. doi: 10.2147/OTT.S184560. PMID: 30863097; PMCID: PMC6388962.IF=3.337

 

Wu Y, Wang H, Zhi J, Hu L, Hou X, Ruan X, Zheng X, Liu H, Gao M. BRMS1 downregulation is a poor prognostic biomarker in anaplastic thyroid carcinoma patients. Onco Targets Ther. 2019 Aug 28;12:6937-6945. doi: 10.2147/OTT.S219506. PMID: 31695409; PMCID: PMC6718127. IF=3.337

 

Zhang J, Hu L, Wang H, Zhi J, Hou X, Wu Y, Zheng X, Gao M. Functional analysis and clinical significance of the isocitrate dehydrogenase 2 gene in papillary thyroid carcinoma. Cancer Manag Res. 2019 May 1;11:3765-3777. doi: 10.2147/CMAR.S194920. PMID: 31118795; PMCID: PMC6503344.IF=2.886

 

Wei S, Yun X, Ruan X, Wei X, Zheng X, Gao M. Identification of potential pathogenic candidates or diagnostic biomarkers in papillary thyroid carcinoma using expression and methylation profiles. Oncol Lett. 2019 Dec;18(6):6670-6678. doi: 10.3892/ol.2019.11059. Epub 2019 Nov 5. PMID: 31814850; PMCID: PMC6888281.IF=2.311

 

Zhao J, Liu P, Yu Y, Zhi J, Zheng X, Yu J, Gao M. Comparison of diagnostic methods for the detection of a BRAF mutation in papillary thyroid cancer. Oncol Lett. 2019 May;17(5):4661-4666. doi: 10.3892/ol.2019.10131. Epub 2019 Mar 8. PMID: 30988823; PMCID: PMC6447932. IF=2.311

 

2018

 

Gao M, Ge M, Ji Q, Cheng R, Lu H, Guan H, Cui W, Gao L, Gao Z, Guo L, Guo Z, Huang T, Huang X, Lin Y, Liu Q, Ni X, Qin J, Ren L, Shan Z, Sun H, Wang X, Xu Z, Yu Y, Zhang B, Zhao D, Zheng Y, Zhu J, Zheng X, Chinese Association Of Thyroid Oncology Cato China Anti-Cancer Association. 2017 Chinese expert consensus on the clinical application of serum marker for thyroid cancer. Cancer Biol Med. 2018 Nov;15(4):468-477. doi: 10.20892/j.issn.2095-3941.2018.0084. PMID: 30766757; PMCID: PMC6372917.IF=5.432

 

Meng X, Yu J, Fan Q, Li L, Li W, Song Z, Liu X, Jiang Y, Gao M, Zhang H*. Characteristics and outcomes of non-Hodgkin's lymphoma patients with leptomeningeal metastases. Int J Clin Oncol. 2018 Aug;23(4):783-789. doi: 10.1007/s10147-018-1268-5. Epub 2018 Mar 20. PMID: 29558001; PMCID: PMC6097078.IF=2.879

 

Zhi J, Zhao J, Gao M, Pan Y, Wu J, Li Y, Li D, Yu Y, Zheng X. Impact of major different variants of papillary thyroid microcarcinoma on the clinicopathological characteristics: the study of 1041 cases. Int J Clin Oncol. 2018 Feb;23(1):59-65. doi: 10.1007/s10147-017-1170-6. Epub 2017 Jul 25. PMID: 28744725; PMCID: PMC5809566.IF=2.879

 

Jia Y, Zhang C, Hu C, Yu Y, Zheng X, Li Y, Gao M. EGFR inhibition enhances the antitumor efficacy of a selective BRAF V600E inhibitor in thyroid cancer cell lines. Oncol Lett. 2018 May;15(5):6763-6769. doi: 10.3892/ol.2018.8093. Epub 2018 Feb 21. PMID: 29616135; PMCID: PMC5876456.IF=2.311

 

Zhang J, Zhang T, Wu N, Zhao X, Wang Q, Jiang Y, Gao M, Gu L. Intracystic papillary carcinoma of the breast: Experience of a major Chinese cancer center. Pathol Res Pract. 2018 Apr;214(4):579-585. doi: 10.1016/j.prp.2018.01.006. Epub 2018 Mar 8. PMID: 29526557.IF=2.051

 

 

荣誉和奖励

 

获得荣誉:

 

1.2009年天津市“五一”劳动奖章

 

2.2011年,天津市“131创新性人才培养工程”第一层次人选(首批)

 

3.2012年中国抗癌协会先进工作者

 

4.2014年,天津市“131创新性人才团队”带头人(首批)

 

5.2015年天津市劳动模范

 

6.2015年天津医科大学优秀博士学位论文导师

 

7.2018年,国务院特殊津贴

 

8.2018年,天津医科大学肿瘤医院第二批杰出学者

 

9.2018年,天津市海河医学学者(首批)

 

10.2020年,天津名医(首批)

 

11.2020年,第四届国之名医

 

科技奖励:

 

1.1995年,天津市卫生局医学科技进步一等奖,第二完成人

 

2.1995年,天津市科学技术进步奖三等奖,第二完成人,

 

3.1996年,天津市科学技术发明三等奖

 

4.1998年,国家科技成果完成者,第二完成人

 

5.2005年,天津市科学技术进步奖三等奖,第一完成人

 

6.2008年,天津市科学技术进步奖二等奖,第一完成人

 

7.2017年,天津市科学技术进步奖二等奖,第一完成人

 

9.2018年,中国抗癌协会科技奖二等奖,第一完成人

 

10.2018年,中华医学科技奖三等奖,第一完成人

 

11.2021年,天津市科学技术进步奖一等奖,第一完成人

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